Conjunctival melanomas harbor BRAF and NRAS mutations--Letter.
نویسندگان
چکیده
tions and similarities in chromosomal gains and losses (1). Specifically, 27% of 78 primary or locally recurrent conjunctival melanoma samples harbored a BRAF V600E mutation. Another study also demonstrated BRAF V600E mutations in 58% of conjunctival melanomas (primary and metastatic) (2). The incidence of this mutation approximates that reported in cutaneous melanoma (3). Now that two phase III studies have demonstrated marked antitumor activity of the BRAF inhibitors vemur-
منابع مشابه
Human Cancer Biology Conjunctival Melanomas Harbor BRAF and NRAS Mutations and Copy Number Changes Similar to Cutaneous and Mucosal Melanomas
Purpose:Conjunctivalmelanoma is a rare but potentially deadly tumor of the eye. Despite effective local therapies, recurrence and metastasis remain frequent. Once the tumor has metastasized, treatment options are limited and the prognosis is poor. To date, little is known of the genetic alterations in conjunctival
متن کاملConjunctival melanomas harbor BRAF and NRAS mutations and copy number changes similar to cutaneous and mucosal melanomas.
PURPOSE Conjunctival melanoma is a rare but potentially deadly tumor of the eye. Despite effective local therapies, recurrence and metastasis remain frequent. Once the tumor has metastasized, treatment options are limited and the prognosis is poor. To date, little is known of the genetic alterations in conjunctival melanomas. EXPERIMENTAL DESIGN We conducted genetic analysis of 78 conjunctiva...
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Purpose To evaluate BRAF, NRAS, and GNAQ mutations in surgical specimens of common and blue conjunctival melanocytic nevi. Methods Surgical specimens from 25 conjunctival melanocytic nevi (23 common and 2 blue) of 25 patients were evaluated. All common nevi were analyzed immunohistochemically for the expression of BRAF V600E or NRAS Q61R. One lesion with negative immunoreactivity and for all ...
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عنوان ژورنال:
- Clinical cancer research : an official journal of the American Association for Cancer Research
دوره 19 22 شماره
صفحات -
تاریخ انتشار 2013